Relationship between vitamin D status and the vaginal microbiome during pregnancy.

ABSTRACT:

Objective

Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome.

Study design

Subjects were assigned to a treatment (4400 IU) or a control group (400 IU vitamin D daily), sampled three times during pregnancy, and vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D [25(OH)D] concentrations were examined.

Result

Gestational age and ethnicity were significantly associated with the microbiome. M

SUBMITTER: Jefferson KK 

PROVIDER: S-EPMC6535112 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature