Dataset Information
Relationship between vitamin D status and the vaginal microbiome during pregnancy.
Ontology highlight
ABSTRACT: Objective
Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome.Study design
Subjects were assigned to a treatment (4400 IU) or a control group (400 IU vitamin D daily), sampled three times during pregnancy, and vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D [25(OH)D] concentrations were examined.Result
Gestational age and ethnicity were significantly associated with the microbiome. Megasphaera correlated negatively (p = 0.0187) with 25(OH)D among women of African ancestry. Among controls, women of European ancestry exhibited a positive correlation between plasma 25(OH)D and L. crispatus abundance.Conclusion
Certain vaginal bacteria are associated with plasma 25(OH)D concentration.
SUBMITTER: Jefferson KK
PROVIDER: S-EPMC6535112 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Relationship between vitamin D status and the vaginal microbiome during pregnancy.
Journal of perinatology : official journal of the California Perinatal Association 20190311 6
<h4>Objective</h4>Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome.<h4>Study design</h4>Subjects were assigned to a treatment (4400 ...[more]
