Fabrication and Characterization of Electrospun Decellularized Muscle-Derived Scaffolds.

ABSTRACT: Although skeletal muscle has a high potential for self-repair, volumetric muscle loss can result in impairment beyond the endogenous regenerative capacity. There is a clinical need to improve on current clinical treatments that fail to fully restore the structure and function of lost muscle. Decellularized extracellular matrix (dECM) scaffolds have been an attractive platform for regenerating skeletal muscle, as dECM contains many biochemical cues that aid in cell adhesion, proliferation, and differentiation. However, there is limited capacity to tune physicochemical properties in current dECM technologies to improve outcome. In this study, we aim to create a novel, high-throughput technique to fabricate dECM scaffolds with tunable physicochemical properties while retaining proregenerative

SUBMITTER: Smoak MM 

PROVIDER: S-EPMC6535957 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature