Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability.

ABSTRACT: Transcranial focused ultrasound (FUS) combined with intravenously circulating microbubbles can transiently and selectively increase blood-brain barrier permeability to enable targeted drug delivery to the central nervous system, and is a technique that has the potential to revolutionize the way neurological diseases are managed in medical practice. Clinical testing of this approach is currently underway in patients with brain tumors, early Alzheimer's disease, and amyotrophic lateral sclerosis. A major challenge that needs to be addressed in order for widespread clinical adoption of FUS-mediated blood-brain barrier permeabilization to occur is the development of systems and methods for real-time treatment monitoring and control, to ensure that safe and effective acoustic exposure levels ar

SUBMITTER: Jones RM 

PROVIDER: S-EPMC6540854 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature