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Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer.

ABSTRACT: Although TC2N has proven to be an oncogene in lung cancer, its biological function and molecular mechanisms in other cancer still remains unclear. Here, we investigate in breast cancer that TC2N expression is sharply overexpressed in breast cancer specimens compared with normal breast specimens, and the low TC2N expression was associated with advanced stage, lymphatic metastasis, larger tumors and shorter survival time. Upregulation of TC2N significantly restrains breast cancer cell proliferation in vitro and tumor growth in vivo. Mechanistically, TC2N blocks AKT signaling in a PI3K dependent and independent way through weakening the interaction between ALK and p55? or inhibiting the binding of EBP1 and AKT. To sum up, these results unmask an ambivalent role of TC2N in cancer, providing a promising inhibitor for PI3K-AKT signaling.

SUBMITTER: Hao XL

PROVIDER: S-EPMC6541591 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer.

Hao Xiang-Lin XL Gao Li-Yun LY Deng Xiao-Juan XJ Han Fei F Chen Hong-Qiang HQ Jiang Xiao X Liu Wen-Bin WB Wang Dan-Dan DD Chen Jian-Ping JP Cui Zhi-Hong ZH Ao Lin L Cao Jia J Liu Jin-Yi JY

Cell death & disease 20190529 6

Although TC2N has proven to be an oncogene in lung cancer, its biological function and molecular mechanisms in other cancer still remains unclear. Here, we investigate in breast cancer that TC2N expression is sharply overexpressed in breast cancer specimens compared with normal breast specimens, and the low TC2N expression was associated with advanced stage, lymphatic metastasis, larger tumors and shorter survival time. Upregulation of TC2N significantly restrains breast cancer cell proliferatio ...[more]

PMID: 31142739

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