Inherited mtDNA variations are not strong risk factors in human prion disease.
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ABSTRACT:
SUBMITTER: Hudson G
PROVIDER: S-EPMC6542657 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Inherited mtDNA variations are not strong risk factors in human prion disease.
Hudson Gavin G Uphill James J Hummerich Holger H Blevins Janice J Gambetti Pierluigi P Zerr Inga I Collinge John J Mead Simon S Chinnery Patrick F PF
Neurobiology of aging 20150710 10
Aside from variation in the prion protein gene, genetic risk factors for sporadic Creutzfeldt-Jakob disease remain elusive. Given emerging evidence implicating mitochondrial dysfunction in the pathogenesis of the disorders, we studied the role of inherited mitochondrial DNA variation in a 2255 sporadic prion disease cases and 3768 controls. Our analysis indicates that inherited mitochondrial DNA variation does not have a major role in the risk of developing the disorder. ...[more]
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