SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors.

ABSTRACT: Induction of programmed DNA damage and its recognition and repair are fundamental for B cell development. The ssDNA-binding protein SSB1 has been described in human cells as essential for the recognition and repair of DNA damage. To study its relevance for B cells, we recently developed Ssb1 ^-/- and conditional Ssb1 ^-/- mice. Although SSB1 loss did not affect B cell development, Ssb1 ^-/- cells exhibited compensatory expression of its homolog SSB2. We have now generated Ssb2 ^-/- mice and show in this study that SSB2 is also dispensable for B cell development and DNA damage response activation. In contrast to the single loss of Ssb1 or Ssb2, however, combined SSB1/2 deficiency caused a defect in early B cel

SUBMITTER: Pfeifer M 

PROVIDER: S-EPMC6545462 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature