Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.

ABSTRACT:

Objective

To estimate the efficacy of common treatments for vulvodynia: topical lidocaine monotherapy, oral desipramine monotherapy, and lidocaine-desipramine combined therapy.

Methods

A 12-week randomized, double-blinded, placebo-controlled trial was conducted on 133 vulvodynia-afflicted women assigned to four treatment arms: placebo tablets-placebo cream, desipramine tablets-placebo cream, placebo tablets-lidocaine cream, and desipramine tablets-lidocaine cream. The tampon test was selected as primary end point using a modified intention-to-treat analysis. Twelve secondary end points were also examined. At completion of the 12-week randomized phase, women were examined "open label" through 52 weeks postrandomization.

Results

All treatment arms reported substantial t

SUBMITTER: Foster DC 

PROVIDER: S-EPMC6545923 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature