Ontology highlight
ABSTRACT:
SUBMITTER: Malagrino F
PROVIDER: S-EPMC6547694 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20190604 1
SH3 domains are very abundant protein-protein interactions modules, involved in the regulation of several cellular processes. Whilst they have been associated to allosteric communication pathways between contiguous domains in multi-domain proteins, there is lack of information regarding the intra-domain allosteric cross-talk within the SH3 moiety. Here we scrutinize the presence of an allosteric network in the C-terminal SH3 domain of Grb2 protein, upon binding the Grb2-associated binding 2 prot ...[more]