Adjuvant chemotherapy versus observation after radical cystectomy in patients with node-positive bladder cancer.

ABSTRACT: This retrospective study compared adjuvant chemotherapy (AC) versus observation after radical cystectomy (RC) in patients with node-positive bladder cancer (pN+). Outcomes were reviewed in patients with pTanyN1-3M0 bladder cancer who underwent RC with or without AC between 1995 and 2017. Baseline characteristics between the two groups were controlled with inverse probability of treatment weighting (IPTW)-adjusted analyses. Of 281 enrolled patients, the 3-year IPTW-adjusted rates of overall survival was higher in the AC group than the RC group (46.4% vs. 33.7%, p?=?0.024). AC was an independent predictor of overall survival (hazard ratio?=?0.48; P?

SUBMITTER: Pak S 

PROVIDER: S-EPMC6549178 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature