Intellectual disability and autism spectrum disorders 'on the fly': insights from Drosophila.

ABSTRACT: Intellectual disability (ID) and autism spectrum disorders (ASD) are frequently co-occurring neurodevelopmental disorders and affect 2-3% of the population. Rapid advances in exome and genome sequencing have increased the number of known implicated genes by threefold, to more than a thousand. The main challenges in the field are now to understand the various pathomechanisms associated with this bewildering number of genetic disorders, to identify new genes and to establish causality of variants in still-undiagnosed cases, and to work towards causal treatment options that so far are available only for a few metabolic conditions. To meet these challenges, the research community needs highly efficient model systems. With an increasing number of relevant assays and rapidly developing novel met

SUBMITTER: Coll-Tane M 

PROVIDER: S-EPMC6550041 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature