Epigenome-wide meta-analysis of DNA methylation and childhood asthma.

ABSTRACT:

Background

Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis.

Objective

We sought to identify differential DNA methylation in newborns and children related to childhood asthma.

Methods

Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions.

Results

In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, fal

SUBMITTER: Reese SE 

PROVIDER: S-EPMC6556405 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature