Circulating levels of inflammatory markers and DNA methylation, an analysis of repeated samples from a population based cohort.

ABSTRACT: DNA methylation in blood may adapt to conditions affecting our health, such as inflammation, and multiple studies have identified differential DNA methylation related to smoking, obesity and various diseases. The purpose of this study was to evaluate previously reported, and explore possible new, associations between levels of inflammatory markers and DNA methylation in blood. We used a well-characterized study population consisting of 127 individuals, all of whom were participants in the population-based Västerbotten Intervention Programme cohort and had provided two blood samples, ten years apart. Levels of CRP and 160 other proteins were measured in plasma, and DNA methylation levels (assessed using the 850K Illumina Infinium MethylationEPIC BeadChip) were measured in white blood cell D

SUBMITTER: Myte R 

PROVIDER: S-EPMC6557598 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature