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Proteomics of Bordetella pertussis whole-cell and acellular vaccines.

ABSTRACT:

Objectives

Bordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host-pathogen interaction and clonal distribution of strains, in addition to Corynebacterium diphtheriae and Clostridium tetani toxoid vaccines, also whole-cell and acellular pertussis vaccines were analyzed by mass spectrometry.

Data description

LC-MS/MS spectra were generated and analyzed using B. pertussis genome data and proteins present in whole-cell and acellular pertussis vaccines were identified. Subcellular localization of proteins and presence of signal peptides was determined bioinformatically.

SUBMITTER: Moller J

PROVIDER: S-EPMC6558669 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Proteomics of Bordetella pertussis whole-cell and acellular vaccines.

Möller Jens J Kraner Max Edmund ME Burkovski Andreas A

BMC research notes 20190610 1

<h4>Objectives</h4>Bordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host-pathogen interaction and clonal distribution of strains, in addition to Corynebacterium diphtheriae and Clostridium tetani toxoid vaccines, also whole-cell and acellular pertussis vaccines were analyzed by mass spectrometry.<h4>Data description</h4>LC-MS/MS ...[more]

PMID: 31182148

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