VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence.

ABSTRACT: Aim: To determine if selected serotonergic and noradrenergic gene variants are associated with heroin addiction. Subjects & methods: A total of 126 variants in 19 genes in subjects with Dutch European ancestry from The Netherlands. Subjects included 281 opioid-dependent volunteers in methadone maintenance or heroin-assisted treatment, 163 opioid-exposed but not opioid-dependent volunteers who have been using illicit opioids but never became opioid-dependent and 153 healthy controls. Results: Nominal associations were indicated for 20 variants in six genes including an experiment-wise significant association from the combined effect of three SLC18A2 SNPs (rs363332, rs363334 and rs363338) with heroin dependence (p_final = 0.047). Conclusion: Furth

SUBMITTER: Randesi M 

PROVIDER: S-EPMC6566135 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature