Surgical resection versus ablation for early-stage hepatocellular carcinoma: A retrospective cohort analysis.

ABSTRACT:

Background

The most appropriate treatment for early-stage hepatocellular carcinoma (HCC) remains unclear. This study compared the association of resection versus ablation with overall survival (OS) in patients with early-stage HCC.

Methods

Using the National Cancer Database (NCDB), patients diagnosed with stage I/II HCC between 2004 and 2014 were identified. Cox analysis was used to determine predictors of OS.

Results

We identified 53,161 patients, of whom 15.9% underwent ablation and 14.5% underwent resection. Patients with fewer comorbidities, larger tumors, and private insurance were more likely to undergo resection. Resection was associated with significantly improved OS compared to ablation (HR 0.58, 95% CI 0.54-0.61, p < 0.001), at all tumor sizes (p < 0.05) and

SUBMITTER: Lee GC 

PROVIDER: S-EPMC6571152 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature