The genetic basis of 3-hydroxypropanoate metabolism in Cupriavidus necator H16.

ABSTRACT:

Background

3-Hydroxypropionic acid (3-HP) is a promising platform chemical with various industrial applications. Several metabolic routes to produce 3-HP from organic substrates such as sugars or glycerol have been implemented in yeast, enterobacterial species and other microorganisms. In this study, the native 3-HP metabolism of Cupriavidus necator was investigated and manipulated as it represents a promising chassis for the production of 3-HP and other fatty acid derivatives from CO₂ and H₂.

Results

When testing C. necator for its tolerance towards 3-HP, it was noted that it could utilise the compound as the sole source of carbon and energy, a highly undesirable trait in the context of biological 3-HP production which required eliminatio

SUBMITTER: Arenas-Lopez C 

PROVIDER: S-EPMC6572756 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature