Cumulative Rheumatic Inflammation Modulates the Bone-Vascular Axis and Risk of Coronary Calcification.

ABSTRACT: Background Rheumatic diseases are related to both abnormal bone turnover and atherogenesis, but a mechanistic link was missing. Methods and Results We investigated the effect of cumulative rheumatic inflammation ( CRI ) on risk of coronary calcification in a retrospective cohort of 145 rheumatoid arthritis patients. A time-adjusted aggregate CRI score was derived by conglomerating all quarterly biomarker encounters of serum C-reactive protein over 60 months immediately preceding computed tomography coronary angiography. Flow cytometry was performed to measure the osteocalcin-positive ( OCN ⁺) CD 34⁺ KDR ⁺ and OCN ⁺ CD 34⁺ circulating endothelial progenitor cells ( EPCs ). Conventional early circulating EPCs CD 34⁺ CD 133

SUBMITTER: Chan YH 

PROVIDER: S-EPMC6585350 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature