Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.
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ABSTRACT:
SUBMITTER: Cordero P
PROVIDER: S-EPMC6591478 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.
Cordero Pablo P Parikh Victoria N VN Chin Elizabeth T ET Erbilgin Ayca A Gloudemans Michael J MJ Shang Ching C Huang Yong Y Chang Alex C AC Smith Kevin S KS Dewey Frederick F Zaleta Kathia K Morley Michael M Brandimarto Jeff J Glazer Nicole N Waggott Daryl D Pavlovic Aleksandra A Zhao Mingming M Moravec Christine S CS Tang W H Wilson WHW Skreen Jamie J Malloy Christine C Hannenhalli Sridhar S Li Hongzhe H Ritter Scott S Li Mingyao M Bernstein Daniel D Connolly Andrew A Hakonarson Hakon H Lusis Aldons J AJ Margulies Kenneth B KB Depaoli-Roach Anna A AA Montgomery Stephen B SB Wheeler Matthew T MT Cappola Thomas T Ashley Euan A EA
Nature communications 20190624 1
Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and obtain genome-wide genotyping and gene expression measurements for a subset of 313. We build failing and non-failing cardiac regulatory gene networks, revealing important regulators and cardiac expression quantitative trait loci (eQTLs). PPP1R3A emerg ...[more]
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