Comparative proteomics of the vector Dermacentor reticulatus revealed differentially regulated proteins associated with pathogen transmission in response to laboratory infection with Rickettsia slovaca.

ABSTRACT:

Background

Tick-borne rickettsial diseases are caused by pathogens acquired from hard ticks. In particular, Rickettsia slovaca, a zoonotic infectious bacterium causing tick-borne lymphadenopathy (TIBOLA), is transmitted by the vectors Dermacentor spp. that can be found all over Europe. Although recent studies point out the extreme complexity of bacteria-induced effects in these blood-feeding vectors, the knowledge of individual molecules involved in the preservation and transmission of the pathogen is still limited. System biology tools, including proteomics, may contribute greatly to the understanding of pathogen-tick-host interactions.

Methods

Herein, we performed a comparative proteomics study of the tick vector Dermacentor reticulatus that was experimentally infected wit

SUBMITTER: Flores-Ramirez G 

PROVIDER: S-EPMC6591964 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature