Preconception folate status and reproductive outcomes among a prospective cohort of folate-replete women.

ABSTRACT:

Background

Most studies of folate metabolism and reproduction have been conducted after pregnancy and in folate-deficient populations. However, measurement of maternal folate status preconceptionally may be most relevant to certain folate-linked early processes preceding a successful pregnancy, and there has been a major increase in folate concentrations in women of childbearing age in high resource settings.

Objective

To examine associations between preconceptional biomarkers of maternal folate status (folate and homocysteine) and reproductive outcomes in folate-replete women.

Study design

Cohort nested within the Effects of Aspirin in Gestation and Reproduction trial, a block-randomized, double-blind, placebo-controlled trial whereby women were randomized to daily l

SUBMITTER: DeVilbiss EA 

PROVIDER: S-EPMC6592753 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature