Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.

ABSTRACT: The liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway has been identified as a new target for cancer therapy, because it controls the glucose and lipid metabolism in response to alterations in nutrients and intracellular energy levels. In the present study, we aimed to identify genetic variants of the LKB1-AMPK pathway genes and their associations with pancreatic cancer (PanC) risk using 15?418 participants of European ancestry from two previously published PanC genome-wide association studies. We found that six novel tagging single-nucleotide polymorphisms (SNPs) (i.e, MAP2 rs35075084 T?>?deletion, PRKAG2 rs2727572 C?>?T and rs34852782 A?>?deletion, TP53 rs9895829 A?>?G, and RPTOR rs62068300 G?>?A and rs3751936 G?>?C) were significantly associated with an increased PanC risk. The multivariate logistic regression model incorporating the number of unfavorable genotypes (NUGs) with adjustment for age and sex showed that carriers with five to six NUGs had an increased PanC risk (odds ratio?=?1.24, 95% confidence interval?=?1.16-1.32 and P??0.9) withRPTOR rs62068300, P?

SUBMITTER: Xu X 

PROVIDER: S-EPMC6602843 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature