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Autophagy and its regulation by ginseng components.


ABSTRACT: Autophagy is the sequential process whereby cell components are degraded, which can occur due to nutrient deprivation. Its regulation has an essential role in many diseases, functioning in both cell survival and cell death. Autophagy starts when mTORC1 is inhibited, resulting in the activation of several complexes to form a cargo that fuses with a lysosome, where it undergoes degradation. In this review, we describe a plant extract that is well known in Korea, namely Korean ginseng extract; we studied how its derivatives and metabolites can regulate autophagy and thus mediate the pathogenesis of certain diseases.

SUBMITTER: Qomaladewi NP 

PROVIDER: S-EPMC6606841 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Autophagy and its regulation by ginseng components.

Qomaladewi Nurinanda Prisky NP   Kim Mi-Yeon MY   Cho Jae Youl JY  

Journal of ginseng research 20190102 3


Autophagy is the sequential process whereby cell components are degraded, which can occur due to nutrient deprivation. Its regulation has an essential role in many diseases, functioning in both cell survival and cell death. Autophagy starts when mTORC1 is inhibited, resulting in the activation of several complexes to form a cargo that fuses with a lysosome, where it undergoes degradation. In this review, we describe a plant extract that is well known in Korea, namely Korean ginseng extract; we s  ...[more]

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