The TNF family member TL1A induces IL-22 secretion in committed human T_h17 cells via IL-9 induction.

ABSTRACT: TL1A contributes to the pathogenesis of several chronic inflammatory diseases, including those of the bowel by enhancing T_H1, T_H17, and T_H2 responses. TL1A mediates a strong costimulation of these T_H subsets, particularly of mucosal CCR9⁺ T cells. However, the signaling pathways that TL1A induces in different T_H subsets are incompletely understood. We investigated the function of TL1A on human T_H17 cells. TL1A, together with TGF-β, IL-6, and IL-23, enhanced the secretion of IL-17 and IFN-γ from human CD4⁺ memory T cells. TL1A induced expression of the transcription factors BATF and T-bet that correlated with the secretion of IL-17 and IFN-γ. In contrast, TL1A alone induced high levels of IL-22 in memory

SUBMITTER: Thomas LS 

PROVIDER: S-EPMC6608031 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature