Effectiveness of integrase strand transfer inhibitors among treatment-experienced patients in a clinical setting.

ABSTRACT:

Objective

Characterize virologic and immunologic outcomes of INSTI-based antiretroviral therapy (ART) in experienced patients with and without virologic failure.

Design

Prospective clinical cohort.

Methods

ART-experienced, INSTI-naive participants in the University of North Carolina Center for AIDS Research HIV Clinical Cohort (UCHCC) initiating an INSTI-containing regimen 2007-2016 were followed from INSTI initiation (baseline) to the earliest of: outcome of interest, loss to follow-up (LTFU, 1 year without clinical visit), or death. Outcomes of interest were virologic failure (first of two consecutive viral loads at least 200 copies/ml more than 2 weeks apart, or one viral load ≥200 before LTFU) and immune recovery (first CD4 ≥500 cells/μl). Patients with baseline v

SUBMITTER: Davy-Mendez T 

PROVIDER: S-EPMC6608711 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature