HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.

ABSTRACT:

Background

Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS), which leads to significant morbidity and mortality and commonly occurs in the setting of combination antibiotic therapy, affecting future treatment choices. Variations in HLA class I in particular have been associated with serious T cell-mediated adverse drug reactions, which has led to preventive screening strategies for some drugs.

Objective

We sought to determine whether variation in the HLA region is associated with vancomycin-induced DRESS.

Methods

Probable vancomycin-induced DRESS cases were matched 1:2 with tolerant control subjects based on sex, race, and age by using BioVU, Vanderbilt's deidentified electronic healt

SUBMITTER: Konvinse KC 

PROVIDER: S-EPMC6612297 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature