The RNA binding protein HuR influences skeletal muscle metabolic flexibility in rodents and humans.

ABSTRACT:

Background

Metabolic flexibility can be assessed by changes in respiratory exchange ratio (RER) following feeding. Though metabolic flexibility (difference in RER between fasted and fed state) is often impaired in individuals with obesity or type 2 diabetes, the cellular processes contributing to this impairment are unclear.

Materials and methods

From several clinical studies we identified the 16 most and 14 least metabolically flexible male and female subjects out of >100 participants based on differences between 24-hour and sleep RER measured in a whole-room indirect calorimeter. Global skeletal muscle gene expression profiles revealed that, in metabolically flexible subjects, transcripts regulated by the RNA binding protein, HuR, are enriched. We generated and characteriz

SUBMITTER: Mynatt RL 

PROVIDER: S-EPMC6624076 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature