Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma risk in Chinese males.

ABSTRACT:

Background

Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent malignant neoplasms of the upper respiratory tract. Studies have confirmed that an unstable chromosome constitution promotes the progress of laryngeal tumorigenesis, and ACYP2 has been confirmed as a telomere length-related gene. However, to date, the association between ACYP2 polymorphisms and LSCC susceptibility has not been investigated.

Methods

We performed this study to explore the effect of 11 single-nucleotide polymorphisms (SNPs) in ACYP2 on LSCC susceptibility in Chinese Han males. Unconditional logistic regression analysis adjusted for age was used to calculate the odds ratios and 95% confidence intervals.

Results

Based on allele and genotype models, our results showed that rs16

SUBMITTER: Zhao W 

PROVIDER: S-EPMC6625106 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature