Benchmarking subcellular localization and variant tolerance predictors on membrane proteins.

ABSTRACT:

Background

Membrane proteins constitute up to 30% of the human proteome. These proteins have special properties because the transmembrane segments are embedded into lipid bilayer while extramembranous parts are in different environments. Membrane proteins have several functions and are involved in numerous diseases. A large number of prediction methods have been introduced to predict protein subcellular localization as well as the tolerance or pathogenicity of amino acid substitutions.

Results

We tested the performance of 22 tolerance predictors by collecting information on membrane proteins and variants in them. The analysis indicated that the best tools had similar prediction performance on transmembrane, inside and outside regions of transmembrane proteins and comparable

SUBMITTER: Orioli T 

PROVIDER: S-EPMC6631444 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature