Ontology highlight
ABSTRACT:
SUBMITTER: Grootjans J
PROVIDER: S-EPMC6637967 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20190301 6430
Immunoglobulin A (IgA) is the major secretory immunoglobulin isotype found at mucosal surfaces, where it regulates microbial commensalism and excludes luminal factors from contacting intestinal epithelial cells (IECs). IgA is induced by both T cell-dependent and -independent (TI) pathways. However, little is known about TI regulation. We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. IEC ER stress causes TI ...[more]