Subtyping of microsatellite instability-high colorectal cancer.

ABSTRACT:

Background

Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) generally have a better prognosis than patients with microsatellite stable (MSS) CRC. However, some MSI-H CRC patients do not gain overall survival benefits from immune checkpoint-blockade treatment. In other words, heterogeneity within the subgroup of MSI-H tumors remains poorly understood. Thus, an in-depth molecular characterization of MSI-H tumors is urgently required.

Methods

Here, we use nonnegative matrix factorization (NMF)-based consensus clustering to define CRC MSI-H subtypes in The Cancer Genome Atlas and a French multicenter cohort GSE39582. CIBERSORT was used to calculate the proportions of 22 lymphocytes in tumor tissue in MSI-H subtypes.

Results

MSI-H CRC samples b

SUBMITTER: Hu W 

PROVIDER: S-EPMC6647262 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature