A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer.

ABSTRACT:

Background

Our study aimed to determine the effect of probiotic consumption containing six viable microorganisms of 30 × 10¹⁰ cfu Lactobacillus and Bifidobacteria strains for six months on clinical outcomes and inflammatory cytokines (TNF-α, IFN-γ, IL-6, IL-10, IL-12, IL-17A, IL-17C and IL-22) in patients with colorectal cancer.

Methods

Fifty-two patients with colorectal cancer were randomized at four weeks after surgery to receive either a placebo (n = 25) or 30 billion colony-forming unit (CFU) of a mixture of six viable strains including 107 mg of Lactobacillus acidophilus BCMC® 12,130, Lactobacillus lactis BCMC® 12,451, Lactobacillus casei subsp BCMC® 12,313, Bifidobacterium longum BCMC® 02120, Bifidobacterium bifidum BCMC® 02290 and Bifidobacterium infantis B

SUBMITTER: Zaharuddin L 

PROVIDER: S-EPMC6657028 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature