Integrated analysis of lncRNA, miRNA and mRNA expression profiling in patients with systemic lupus erythematosus.

ABSTRACT:

Introduction

A great deal of research has reported dysregulated expression of genes in systemic lupus erythematosus (SLE). This study aimed to analyze the lncRNA, miRNA and mRNA expression profile in SLE.

Material and methods

RNA sequencing (RNA-seq) was used to detect the dysregulated RNAs in SLE. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis were used to explore the function of these differentially expressed RNAs.

Results

2,353 lncRNAs, 827 mRNAs and 24 miRNAs were shown to be differentially expressed. GO analyses demonstrated that differentially expressed RNAs were enriched in a variety of molecular functions and biological processes including ribonucleotide, protein serine/threonine kinase activity function, regulation of

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6657242 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature