Deletions in guaBA and htrA but not clpX or rfaL constitute a live-attenuated vaccine strain of Salmonella Newport to protect against serogroup C_2-C₃ Salmonella in mice.

ABSTRACT: Non-typhoidal Salmonella (NTS) are a leading cause of foodborne infections worldwide, and serogroups B, C₁, C_2-C₃ and D are the most common serogroups associated with human disease. While live vaccine candidates that protect against S. Typhimurium (serogroup B) and S. Enteritidis (serogroup D) have been described by us and others, far less effort has been directed towards vaccines that target either serogroup C₁ or C_2-C₃ Salmonella. Here we describe a Salmonella Newport-based live-attenuated vaccine (serogroup C_2-C₃). Deletion of the genes clpX or rfaL, previously used in live vaccines to attenuate S. Typhimurium and/or S. Enteritidis, faile

SUBMITTER: Fuche FJ 

PROVIDER: S-EPMC6663134 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature