Is folic acid safe for non-muscle-invasive bladder cancer patients? An evidence-based cohort study.

ABSTRACT:

Background

Patients with cancer are highly concerned about food choices and dietary supplements that may affect their treatment outcomes. Excess folic acid (synthetic folate) from supplements or fortification can lead to accumulation of unmetabolized folic acid in the systemic circulation and urine and may promote cancer growth, especially among those with neoplastic alterations.

Objective

We investigated the prospective association between synthetic compared with natural folate intake and clinical outcomes in non-muscle-invasive bladder cancer (NMIBC), which is a highly recurrent disease.

Design

In a cohort of 619 NMIBC patients, folate intake at diagnosis was assessed with a previously validated food-frequency questionnaire and categorized according to tertiles. Aft

SUBMITTER: Tu H 

PROVIDER: S-EPMC6669327 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature