Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Lopez E
PROVIDER: S-EPMC6675591 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cell metabolism 20190411 6
Choline is a vitamin-like nutrient that is taken up via specific transporters and metabolized by choline kinase, which converts it to phosphocholine needed for de novo synthesis of phosphatidylcholine (PC), the main phospholipid of cellular membranes. We found that Toll-like receptor (TLR) activation enhances choline uptake by macrophages and microglia through induction of the choline transporter CTL1. Inhibition of CTL1 expression or choline phosphorylation attenuated NLRP3 inflammasome activat ...[more]