Circulating CXCR5-PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes.

ABSTRACT: AIMS/HYPOTHESIS:Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to play a critical role in the disease process. Here, we aimed to evaluate the role of a recently described subset, C-X-C motif chemokine receptor type 5-negative, programmed cell death protein 1-positive (CXCR5-PD-1hi) peripheral T helper (Tph) cells, in human type 1 diabetes. METHODS:The phenotype of blood CXCR5-PD-1hi CD4+ T cells was analysed by multicolour flow cytometry. The frequencies of circulating CXCR5-PD-1hi T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive (AAb+) at-risk children and 84 autoantibody-negat

SUBMITTER: Ekman I 

PROVIDER: S-EPMC6677711 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature