Directional entry and release of Zika virus from polarized epithelial cells.

ABSTRACT:

Background

Both vector borne and sexual transmission of Zika virus (ZIKV) involve infection of epithelial cells in the initial stages of infection. Epithelial cells are unique in their ability to form polarized monolayers and their barrier function. Cell polarity induces an asymmetry in the epithelial monolayer, which is maintained by tight junctions and specialized sorting machinery. This differential localization can have a potential impact of virus infection. Asymmetrical distribution of a viral receptor can restrict virus entry to a particular membrane while polarized sorting can lead to a directional release of virions. The present study examined the impact of cell polarity on ZIKV infection and release.

Methods

A polarized Caco-2 cell model we described previously was

SUBMITTER: Tamhankar M 

PROVIDER: S-EPMC6688342 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature