Association of menopausal characteristics and risk of coronary heart disease: a pan-European case-cohort analysis.

ABSTRACT:

Background

Earlier age at menopause has been associated with increased risk of coronary heart disease (CHD), but the shape of association and role of established cardiovascular risk factors remain unclear. Therefore, we examined the associations between menopausal characteristics and CHD risk; the shape of the association between age at menopause and CHD risk; and the extent to which these associations are explained by established cardiovascular risk factors.

Methods

We used data from EPIC-CVD, a case-cohort study, which includes data from 23 centres from 10 European countries. We included only women, of whom 10 880 comprise the randomly selected sub-cohort, supplemented with 4522 cases outside the sub-cohort. We conducted Prentice-weighted Cox proportional hazards regressio

SUBMITTER: Dam V 

PROVIDER: S-EPMC6693816 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature