Disrupted regulation of serpinB9 in circulating T cells is associated with an increased risk for post-transplant skin cancer.

ABSTRACT: Cutaneous squamous cell carcinoma (cSCC) is a serious complication after organ transplantation and patients benefit from an early risk assessment. We hypothesized that functional differences in circulating T cells may represent risk factors for post-transplant cSCC development. Here, we analysed genome-wide DNA methylation of circulating T cells of kidney transplant recipients before the clinical onset of cSCC, to identify differences associated with post-transplant cSCC development. This analysis identified higher DNA methylation of SERPINB9, which is an intracellular inhibitor of granzyme B, a protein that induces apoptosis in target cells. High DNA methylation of SERPINB9 in circulating T cells was confirmed in a second patient cohort during recurrent cSCC, indicating that high SERPINB9

SUBMITTER: Peters FS 

PROVIDER: S-EPMC6693965 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature