Estimated dengue force of infection and burden of primary infections among Indian children.

ABSTRACT:

Background

Comprehensive, age-stratified dengue surveillance data are unavailable from India and many more dengue cases occur than are reported. Additional information on dengue transmission dynamics can inform understanding of disease endemicity and infection risk.

Methods

Using age-stratified dengue IgG seroprevalence data from 2556 Indian children aged 5-10 years, we estimated annual force of infection (FOI) at each of 6 sites using a binomial regression model. We estimated the ages by which 50 and 70% of children were first infected; and predicted seroprevalence in children aged 1-10 years assuming constant force-of-infection. Applying these infection rates to national census data, we then calculated the number of primary dengue infections occurring, annually, in Indian

SUBMITTER: Bhavsar A 

PROVIDER: S-EPMC6694619 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature