Identification of aberrantly methylated differentially expressed genes in glioblastoma multiforme and their association with patient survival.

ABSTRACT: Glioblastoma multiforme (GBM) is the most malignant primary tumour type of the central nervous system with limited therapeutic options and poor prognosis, and its pathogenic mechanisms have remained to be fully elucidated. Aberrant DNA methylation is involved in multiple biological processes and may contribute to the occurrence and development of GBM by affecting the expression of certain genes. However, the specific molecular mechanisms remain to be fully elucidated. The present study focused on uncovering differentially expressed genes with altered methylation status in GBM and aimed to discover novel biomarkers for the diagnosis and treatment of GBM. These genes were identified by combined analysis of multiple gene expression and methylation datasets from gene expression omnibus (GSE160

SUBMITTER: Zhang M 

PROVIDER: S-EPMC6704589 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature