Immunomodulatory effect of mesenchymal stem cells in chemical-induced liver injury: a high-dimensional analysis.

ABSTRACT:

Background

The efficacy of mesenchymal stem cell (MSC)-based therapy for acute liver injury (ALI) involves coordination with the hepatic immune system, a complex and coordinated network of immune-cell interactions. However, studies of the immunomodulatory effects of MSCs have focused on a limited number of cell subsets rather than a systematic assessment.

Methods

Carbon tetrachloride (CCl₄) was used to induce ALI in mice. To determine the efficacy of MSCs, ALI mice were injected with MSCs via the tail vein, and histopathological changes, survival rate, and the serum levels of liver enzymes were determined. To assess the immune response induced by MSCs, a mass cytometry panel of 43 metal isotope-tagged antibodies was used to characterize the hepatic immune compartm

SUBMITTER: Liu J 

PROVIDER: S-EPMC6708172 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature