Suppression of the photoparoxysmal response in photosensitive epilepsy with cenobamate (YKP3089).

ABSTRACT:

Objective

To evaluate the effect of cenobamate in patients with photoparoxysmal-EEG response (PPR) to intermittent photic stimulation (IPS) as proof of principle of efficacy in patients with epilepsy.

Methods

In this multicenter, single-blind study, adults with photosensitive epilepsy, with/without concomitant antiepileptic drug therapy, underwent IPS under 3 eye conditions after a single dose of placebo (day -1, day 2) or cenobamate (day 1; 100, 250, or 400 mg). Complete suppression was a standardized photosensitivity range reduction to 0 over ≥1 time points for all eye conditions. Partial suppression was a ≥3-point reduction over ≥3 testing times vs the same time points on day -1 in ≥1 eye condition. Pharmacokinetics and safety were assessed.

Results

Of 6 evaluable

SUBMITTER: Kasteleijn-Nolst Trenite DGA 

PROVIDER: S-EPMC6709996 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature