Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients.

ABSTRACT:

Aims

Breast cancer is the most frequently diagnosed and leading cause of cancer death among women worldwide. It was classified within molecular intrinsic subtypes: luminal A, luminal B, human epidermal growth factor receptor 2-enriched and basal-like. Epinephrine and norepinephrine, released during stress, bind to adrenoceptors. α₂ -adrenoceptors are encoded by the ADRA2A, ADRA2B and ADRA2C genes and β₂ by ADRB2.

Methods

We compiled several publicly available Affymetrix gene expression datasets, obtaining a large cohort of 1924 patients with distant metastasis-free survival (DMFS) data and evaluated the association between adrenoceptor expression, clinicopathological markers and outcome.

Results

ADRA2A high expressing tumours also expressed hormo

SUBMITTER: Rivero EM 

PROVIDER: S-EPMC6710529 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature