Hypersensitivity reactions to high osmolality Total Parenteral Nutrition: a case report.

ABSTRACT:

Background

The full range of allergic reactions to Total Parenteral Nutrition (TPN) remains unknown. Additionally, beyond individual allergens, there may be other factors contributing to TPN hypersensitivity reactions.

Case presentation

We present a case of a patient with negative skin testing to common TPN allergens who had recurrent urticarial reactions to TPN. Her skin reactions resolved once TPN was stopped. Following a literature review, we postulated that the reactions could be due to the high osmolality of her TPN. Consequently, lowering her TPN from 2785 to 1928 mOsm/kg and premedicating with cetirizine resulted in resolution of her urticaria.

Conclusions

When looking at patients who have hypersensitivity reactions to TPN, one must consider that their reaction

SUBMITTER: Pang SA 

PROVIDER: S-EPMC6716805 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature