IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3.

ABSTRACT: Increasing evidence demonstrates that IL-17A promotes tumorigenesis, metastasis, and viral infection. Natural killer (NK) cells are critical for defending against tumors and infections. However, the roles and mechanisms of IL-17A in regulating NK cell activity remain elusive. Herein, our study demonstrated that IL-17A constrained NK cell antitumor and antiviral activity by restraining NK cell maturation. It was observed that the development and metastasis of tumors were suppressed in IL-17A-deficient mice in the NK cell-dependent manner. In addition, the antiviral activity of NK cells was also improved in IL-17A-deficient mice. Mechanistically, ablation of IL-17A signaling promoted generation of terminally mature CD27^-CD11b⁺ NK cells, whereas constitutive IL-17A signa

SUBMITTER: Wang X 

PROVIDER: S-EPMC6717263 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature