Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study.

ABSTRACT:

Objective

To explore whether thyroid stimulating hormone (TSH) concentration in patients with a diagnosis of hypothyroidism is associated with increased all cause mortality and a higher risk of cardiovascular disease and fractures.

Design

Retrospective cohort study.

Setting

The Health Improvement Network (THIN), a database of electronic patient records from UK primary care.

Participants

Adult patients with incident hypothyroidism from 1 January 1995 to 31 December 2017.

Exposure

TSH concentration in patients with hypothyroidism.

Main outcome measures

Ischaemic heart disease, heart failure, stroke/transient ischaemic attack, atrial fibrillation, any fractures, fragility fractures, and mortality. Longitudinal TSH measurements from diagnosis to outco

SUBMITTER: Thayakaran R 

PROVIDER: S-EPMC6719286 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature