Ontology highlight
ABSTRACT:
SUBMITTER: Liechti T
PROVIDER: S-EPMC6719425 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20190620 9
Perturbations in B cells are a hallmark of HIV-1 infection. This is signified by increased numbers of exhausted CD21<sup>neg</sup> memory B cells, driven by continuous antigen-specific and bystander activation. Using high-dimensional flow cytometry, we demonstrate that this exhausted phenotype is also prevalent among peripheral antigen-inexperienced naive and marginal zone (MZ) B cells in acute and chronic HIV-1 infection. A substantial fraction of naive and MZ B cells exhibit down-regulated CD2 ...[more]