Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons.

ABSTRACT: Layer I of the neocortex comprises axonal processes from widespread regions of the brain and a unique population of GABAergic interneurons. Dopamine is known to directly depolarize layer I interneurons, but the underlying mechanism is unclear. Using whole-cell recording techniques in neocortical brain slices, we have examined how dopamine increases excitability of layer I interneurons in postnatal day 7-11 rats. Dopamine (30 microm) caused a 10 mV depolarization of layer I neurons. Paradoxically, neither the D1-like receptor agonist 6-chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide (SKF81297) (1-10 microm) nor the D2-like agonist quinpirole (10 microm) produced a significant depolarization. Depolarization was observed when SKF81297 and quinpirole were coapplied. When G-pro

SUBMITTER: Wu J 

PROVIDER: S-EPMC6725283 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature