Prostaglandin signals from adult germ stem cells delay somatic aging of <i>Caenorhabditis elegans</i>.

ABSTRACT: A moderate reduction of body temperature can induce a remarkable lifespan extension. Here we examine the link between cold temperature, germ line fitness and organismal longevity. We show that low temperature reduces age-associated exhaustion of germ stem cells (GSCs) in Caenorhabditis elegans, a process modulated by thermosensory neurons. Notably, robust self-renewal of adult GSCs delays reproductive aging and is required for extended lifespan at cold temperatures. These cells release prostaglandin E2 (PGE2) to induce cbs-1 expression in the intestine, increasing somatic production of hydrogen sulfide (H₂S), a gaseous signaling molecule that prolongs lifespan. Whereas loss of adult GSCs reduces intestinal cbs-1 expression and cold-induced longevity, applica

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC6726479 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature